Practical synthesis of lespedezol A1
RS Khupse, PW Erhardt
Index: Khupse, Rahul S.; Erhardt, Paul W. Journal of Natural Products, 2008 , vol. 71, # 2 p. 275 - 277
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Citation Number: 20
Abstract
A practical formal synthesis of lespedezol A1 (1) was accomplished in 33% yield for four steps starting from formation of the substituted chalcone. Of particular note is a useful protocol for reduction of the 2-ene bond in the isoflavone intermediate. A significant improvement in the final ring closure when water was scavenged from the reaction is also noteworthy. The ready availability of lespedezol A1 will provide material for further ...
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