Chemical Communications

Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions

M Fischer, H Kählig, W Schmid

Index: Fischer, Michael; Kaehlig, Hanspeter; Schmid, Walther Chemical Communications, 2011 , vol. 47, # 23 p. 6647 - 6649

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Citation Number: 4

Abstract

An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by 19F-NMR.