Synthesis and hypoglycemic activity of N-alkyl-N'-(2-amino-l, 3, 4-thiadiazol-5-ylsulfonyl)-and N-alkyl-N'-(5-sulfamoyl-l, 3, 4-thiadiazol-2-yl)-oxamides

…, PA Bezuglyi, VI Makurina, VA Chubenko…

Index: Chernykh, V. P.; Buluda, Zh. P.; Bezuglyi, P. A.; Makurina, V. I.; Chubenko, V. A.; Voronina, L. N. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 107 - 110 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 33 - 37

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Abstract

N-Substituted N'-arylsulfony!oxamides display marked sugar-reducing activity and are relatively nontoxic [1-3]. We thought it relevant to structure--activity studies to examine the biological activ- ity of N-alkyl-N'-(2-amino-l,3,4-thiadiazol-5-ylsulfonyl)- and N-alkyl-N'-(5~sulfamoyl-l,3,4 - thiadiazol-2-yl)oxamides, in which the sulfonyl group is attached to a heterocycle. We synthesized these groups of compounds by the reactions ... N --J~ J",[----P4 H5OzOOOOO+~N-- ~ ...