Tetrahedron
Synthesis of the four enantiomerically-pure isomers of 15-F2t-isoprostane
DF Taber, K Kanai
Index: Taber, Douglass F.; Kanai, Kazuo Tetrahedron, 1998 , vol. 54, # 39 p. 11767 - 11782
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Citation Number: 36
Abstract
Syntheses of the four enantiomerically-pure isomers of 15-F2t-isoprostane are described. The key step is the lipase-mediated resolution of a pseudo-meso diol, to give the regioisomeric acetates in high enantiomeric purity. Improved procedures for the preparation of the pseudo-meso diol are also reported.
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