Gold-catalyzed one-step practical synthesis of oxetan-3-ones from readily available propargylic alcohols
L Ye, W He, L Zhang
Index: Ye, Longwu; He, Weimin; Zhang, Liming Journal of the American Chemical Society, 2010 , vol. 132, # 25 p. 8550 - 8551
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Citation Number: 169
Abstract
A general solution for the synthesis of various oxetan-3-ones is developed. This reaction uses readily available propargylic alcohols as substrates and proceeds without the exclusion of moisture or air (“open flask”). Notably, oxetan-3-one, a highly valuable substrate for drug discovery, can be prepared in one step from propargyl alcohol in a fairly good yield. The facile formation of the strained oxetane ring provides strong support for the ...
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