Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring

A Tanitame, Y Oyamada, K Ofuji, M Fujimoto…

Index: Tanitame, Akihiko; Oyamada, Yoshihiro; Ofuji, Keiko; Fujimoto, Mika; Suzuki, Kenji; Ueda, Tomohiko; Terauchi, Hideo; Kawasaki, Motoji; Nagai, Kazuo; Wachi, Masaaki; Yamagishi, Jun-Ichi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5515 - 5524

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Citation Number: 121

Abstract

The 4-piperidyl moiety and the pyrazole ring in 1-(3-chlorophenyl)-5-(4-phenoxyphenyl)-3-(4- piperidyl) pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, were transformed to other groups and the in vitro antibacterial activity of the synthesized compounds was evaluated. The selected pyrazole, oxazole and imidazole derivatives showed moderate inhibition against DNA gyrase and ...