A Practical Preparation of Highly Versatile N-Acylpyrroles from 2, 4, 4-Trimethoxybutan-1-amine
T Maehara, R Kanno, S Yokoshima, T Fukuyama
Index: Maehara, Tomoaki; Kanno, Rentaro; Yokoshima, Satoshi; Fukuyama, Tohru Organic Letters, 2012 , vol. 14, # 7 p. 1946 - 1948
Full Text: HTML
Citation Number: 19
Abstract
A novel method for the preparation of N-acylpyrrole is described. The method involves condensation of carboxylic acids with 2, 4, 4-trimethoxybutan-1-amine, followed by acid- mediated cyclization to form the pyrrole ring. The preparative procedure is highly tolerant of a variety of functional groups.
Related Articles:
Iron-catalyzed inexpensive and practical synthesis of N-substituted pyrroles in water
[Azizi, Najmedin; Khajeh-Amiri, Alireza; Ghafuri, Hossein; Bolourtchian, Mohammad; Saidi, Mohammad Reza Synlett, 2009 , # 14 p. 2245 - 2248]