Synthesis and DNA binding and photonicking properties of acridine orange linked by a polymethylene tether to (1, 2-diaminoethane) dichloroplatinum (II)

BE Bowler, LS Hollis, SJ Lippard

Index: Bowler, Bruce E.; Hollis, L. Steven; Lippard, Stephen J. Journal of the American Chemical Society, 1984 , vol. 106, # 20 p. 6102 - 6104

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Citation Number: 85

Abstract

8 oxidation of 5 would yield pseudobenzylisoquinoline 6a, structurally related to the known rugosinone (a)? 0, N-Dimethylation of 6a would provide salt 7, which through base- catalyzed isomerization could lead to pseudobase 8. Reduction of 8 would give rise to ketone 9. Enolization of this ketone, and oxidation of the aromatic methoxyl group to an oxonium ion as in 10, would then set the stage for the formation of the methylenoxy ...

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