Tetrahedron

Efficient one-pot synthesis of β-hydroxyphosphonates: regioselective nucleophilic ring opening reaction of epoxides with triethyl phosphite catalyzed by Al (OTf) 3

S Sobhani, A Vafaee

Index: Sobhani, Sara; Vafaee, Asieh Tetrahedron, 2009 , vol. 65, # 36 p. 7691 - 7695

Full Text: HTML

Citation Number: 23

Abstract

A variety of β-hydroxyphosphonates were produced in high yields by ring opening reaction of different types of epoxides with di/trialkyl phosphite esters catalyzed by Al (OTf) 3. The reactions proceeded with complete chemo-and regioselectivity to give the title compounds. This method is new, simple and efficient for the one-pot synthesis of β-hydroxyphosphonates via direct C–P bond formation.