Studies on models for tetrahydrofolic acid. 8. Hydrolysis and methoxyaminolysis of amidines

BA Burdick, PA Benkovic…

Index: Burdick,B.A. et al. Journal of the American Chemical Society, 1977 , vol. 99, p. 5716 - 5725

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Citation Number: 29

Abstract

Abstract: The hydrolyses and methoxyaminolyses of a series of cyclic amidines and an acyclic analogue were examined in order to assess the possible importance of stereoelectronic control on the breakdown of the ensuing tetrahedral intermediates and to identify kinetically significant steps between these intermediates and the respective kinetic or thermodynamic isomers. All cyclic amidines react to form initially the product of kinetic ...