Preparation, antimicrobial activity, and toxicity of 2??amino??4??arylthiazole derivatives

P Morales??Bonilla, A Pérez??Cardeña…

Index: Morales-Bonilla, Pedro; Perez-Cardena, Andrea; Quintero-Marmol, Esther; Arias-Tellez, Jose Luis; Mena-Rejon, Gonzalo J. Heteroatom Chemistry, 2006 , vol. 17, # 4 p. 254 - 260

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Citation Number: 18

Abstract

Abstract Seven 2-amino-4-aryl-1, 3-thiazoles (1a–g) and their corresponding 2-aminoacetyl (2a–g) and 2-aminoacetyl-5-bromo (3a–g) derivatives were synthesized and tested in vitro against 11 reference strains, three Gram-positive and four Gram-negative bacteria, two yeasts, and two moulds. Toxicity of the compounds was also evaluated using the brine shrimp test. Compounds 1a, 1b, 1e–g, and 3b showed moderate antimicrobial activity at ...