Synthesis of structural analogues of leukotriene B 4 and their receptor binding activity

…, T Nakae, S Sakuyama, M Nishizaki, Y Odagaki…

Index: Konno, Mitoshi; Nakae, Takahiko; Sakuyama, Shigeru; Odagaki, Yoshihiko; Nakai, Hisao; Hamanaka, Nobuyuki Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1621 - 1647

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Citation Number: 6

Abstract

Structural analogues of leukotriene B4 (LTB4) were designed based on the plausible conformation of LTB4 (1). Joining C-7–C-9 of the conformer A or B into an aromatic ring system led to the discovery of benzene analogues 2, 4 and 6a. Joining C-4–C-9 of the conformer C or D into an aromatic ring system led to the discovery of analogues 3, 5 and 7. The compounds examined in this study were evaluated as to their inhibition of [3H] LTB4 ...