Steric and Kinetic Isotope Effects in the Deprotonation of Cation Radicals of NADH Synthetic Analogs

A Anne, S Fraoua, P Hapiot, J Moiroux…

Index: Anne, Agnes; Fraoua, Sylvie; Hapiot, Philippe; Moiroux, Jacques; Saveant, Jean-Michel Journal of the American Chemical Society, 1995 , vol. 117, # 28 p. 7412 - 7421

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Citation Number: 45

Abstract

Abstract: The deprotonation rate constants and kinetic isotope effects of the cation radicals have been determined by combined use of direct electrochemical techniques at micro-and ultramicroelectrodes, redox catalysis, and laser flash photolysis, over a extended series of opposing bases. Significant steric hindrance to deprotonation results from encumbering of the opposing base and of the functional carbon in the cation radical by alkyl groups. ...