Discovery of novel, non-acidic 1, 5-biaryl pyrrole EP 1 receptor antagonists
…, GMP Giblin, P Goldsmith, MP Healy, KS Jandu…
Index: Hall, Adrian; Atkinson, Stephen; Brown, Susan H.; Chessell, Iain P.; Chowdhury, Anita; Giblin, Gerard M.P.; Goldsmith, Paul; Healy, Mark P.; Jandu, Karamjit S.; Johnson, Matthew R.; Michel, Anton D.; Naylor, Alan; Sweeting, Jennifer A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1200 - 1205
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Citation Number: 32
Abstract
Replacement of the carboxylic acid group in a series of previously described 1, 5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high binding efficiency indices.
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[Hall, Adrian; Atkinson, Stephen; Brown, Susan H.; Chessell, Iain P.; Chowdhury, Anita; Clayton, Nicholas M.; Coleman, Tanya; Giblin, Gerard M.P.; Gleave, Robert J.; Hammond, Beverley; Healy, Mark P.; Johnson, Matthew R.; Michel, Anton D.; Naylor, Alan; Novelli, Riccardo; Spalding, David J.; Tang, Sac P. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3657 - 3662]