Homolytic acylation of protonated pyridines and pyrazines with. alpha.-keto acids: the problem of monoacylation
…, MC Nogueira Barbosa, E Vismara
Index: Fontana, Francesca; Minisci, Francesco; Barbosa, Maria Claudia Nogueira; Vismara, Elena Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2866 - 2869
Full Text: HTML
Citation Number: 116
Abstract
The silver-catalyzed decarboxylation of a-keto acids by persulfate leads to acyl radicals, which can effect the selective homolytic acylation of pyridine and pyrazine derivatives. Compared with the previously developed source of acyl radicals by hydrogen abstraction from aldehydes, this procedure is more effective in monoacylation when multiple positions of high nucleophilic reactivity are available in the heterocyclic ring. Although the introduction ...
Related Articles:
[Minisci, Francesco; Recupero, Francesco; Cecchetto, Andrea; Punta, Carlo; Gambarotti, Cristian; Fontana, Francesca; Pedulli, Gian Franco Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 325 - 328]
[Hermann, Christine K. F.; Sachdeva, Yesh P.; Wolfe, James F. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1061 - 1065]
A new, convenient synthesis of monoaroylpyrazines via homolytic substitution
[Heinisch, G.; Loetsch, G. Synthesis, 1988 , # 2 p. 119 - 121]
A new, convenient synthesis of monoaroylpyrazines via homolytic substitution
[Heinisch, G.; Loetsch, G. Synthesis, 1988 , # 2 p. 119 - 121]