ChemMedChem

Synthesis and in vitro Evaluation of West Nile Virus Protease Inhibitors Based on the 2??{6??[2??(5??Phenyl??4H??{1, 2, 4] triazol??3??ylsulfanyl) acetylamino] benzothiazol??2 …

S Samanta, TL Lim, Y Lam

Index: Samanta, Sanjay; Lim, Ting Liang; Lam, Yulin ChemMedChem, 2013 , vol. 8, # 6 p. 994 - 1001

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Citation Number: 12

Abstract

Abstract In recent years, clinical symptoms resulting from West Nile virus (WNV) infection have worsened in severity, with an increased frequency in neuroinvasive diseases among the elderly. As there are presently no successful therapies against WNV for use in humans, continual efforts to develop new chemotherapeutics against this virus are highly desired. The viral NS2B-NS3 protease is a promising target for viral inhibition due to its importance ...