Pyridyloxobutyl adduct O 6-[4-oxo-4-(3-pyridyl) butyl] guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for …

…, XK Liu, SS Hecht, AE Pegg, LA Peterson

Index: Wang; Spratt; Liu; Hecht; Pegg; Peterson Chemical research in toxicology, 1997 , vol. 10, # 5 p. 562 - 567

Full Text: HTML

Citation Number: 99

Abstract

The lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is activated to reactive metabolites that methylate or pyridyloxobutylate DNA. Previous studies demonstrated that pyridyloxobutylated DNA interferes with the repair of O 6-methylguanine (O 6-mG) by O 6-alkylguanine-DNA alkyltransferase (AGT). The AGT reactivity of pyridyloxobutylated DNA was attributed to (pyridyloxobutyl) guanine adducts. One ...