Journal of Fluorine Chemistry

A concise and versatile synthesis of 2-amino-3-cyanopyridine derivatives in 2, 2, 2-trifluoroethanol

S Khaksar, M Yaghoobi

Index: Khaksar, Samad; Yaghoobi, Mandana Journal of Fluorine Chemistry, 2012 , vol. 142, p. 41 - 44

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Citation Number: 25

Abstract

Trifluoroethanol (TFE) is found to be an efficient and recyclable medium in promoting one- pot, four-component coupling reactions of aldehydes, ketones, malononitrile, and ammonium acetate to afford the corresponding 2-amino-3-cyanopyridine derivatives in high yields. The solvent (TFE) can be readily separated from reaction products and recovered in excellent purity for direct reuse.