Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism

…, R Hardeland, MA Pappolla, B Pucci

Index: Durand, Gregory; Poeggeler, Burkhard; Ortial, Stephanie; Polidori, Ange; Villamena, Frederick A.; Boeker, Jutta; Hardeland, Ruediger; Pappolla, Miguel A.; Pucci, Bernard Journal of Medicinal Chemistry, 2010 , vol. 53, # 13 p. 4849 - 4861

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Citation Number: 19

Abstract

Our group has demonstrated that the amphiphilic character of α-phenyl-N-tert-butyl nitrone based agents is a key feature in determining their bioactivity and protection against oxidative toxicity. In this work, we report the synthesis of a new class of amphiphilic amide nitrones. Their hydroxyl radical scavenging activity and radical reducing potency were shown using ABTS competition and ABTS•+ reduction assays, respectively. Cyclic voltammetry was ...