Synthesis and biological activity of some unsaturated 6-azauracil acyclonucleosides
Y Kabbaj, HB Lazrek, JL Barascut…
Index: Kabbaj, Youssef; Lazrek, Hassan Bihi; Barascut, Jean Louis; Imbach, Jean Louis Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 3 p. 161 - 172
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Citation Number: 20
Abstract
A useful route is described for obtaining Z and E unsaturated alkylating agents 3 and 4. Coupling 6-azauracils 5 and 6 with unsaturated alkylating agent followed by the deprotection with H+ resin gave acyclonucleosides 11–14 in good overall yields. Unsaturated acyclonucleosides phosphonates 19 and 20 were prepared using potassium carbonate as base and 4-bromobut-2-enyl diethyl phosphonate 16 as the alkylating agent. ...
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