Bioorganic & medicinal chemistry

Single nucleotide specific detection of DNA by native chemical ligation of fluorescence labeled PNA-probes

C Dose, O Seitz

Index: Dose, Christian; Seitz, Oliver Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 1 p. 65 - 77

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Citation Number: 52

Abstract

DNA-directed chemical ligations provide the opportunity to diagnose DNA sequences with very high sequence specificity. Fluorescent labels have been attached to reactive probes to enable the homogeneous detection of DNA and RNA. However, it has frequently been ...