Journal of medicinal chemistry

Synthesis and anticonvulsant activities of N-benzyl-2-acetamidopropionamide derivatives

D Choi, JP Stables, H Kohn

Index: Choi, Daeock; Stables, James P.; Kohn, Harold Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1907 - 1916

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Citation Number: 134

Abstract

Studies have demonstrated that 2-substituted N-benzyl-2-acetamidoacetamides (2) are potent anticonvulsants. A recent investigation has led to the hypothesis that an important structural feature in 2 for maximal anticonvulsant activity is the placement of a small, substituted heteroatom moiety one atom from the C (2) site. This paper validates this hypothesis. Twelve derivatives of N-benzyl-2-acetamidopropionamide have been ...