Synthesis and properties of some 13??cis and all??trans??retinamides

…, JL Frye, CA O'Dell, MC Thorpe, MC Kirk…

Index: Shealy; Frye; O'Dell; Thorpe; Kirk; Coburn Jr.; Sporn Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 6 p. 745 - 751

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Citation Number: 23

Abstract

Abstract Several 13-cis-retinamides were synthesized from 13-cis-retinoic acid via either 13- cis-retinoyl chloride or 13-cis-1-retinoylimidazole. All-trans-retinoylglycine was prepared from all-trans-retinoyl chloride and ethyl glycinate. Detailed procedures were developed for the preparation of other all-trans-retinamides on a large scale for studies of the chemoprevention of cancer.