α2-Adrenoceptor antagonists: synthesis, pharmacological evaluation, and molecular modeling investigation of pyridinoguanidine, pyridino-2-aminoimidazoline and …
…, JJ Meana, LF Callado, I Rozas
Index: O'Donovan, Daniel H.; Kelly, Brendan; Diez-Cecilia, Elena; Kitson, Martin; Rozas, Isabel New Journal of Chemistry, 2013 , vol. 37, # 8 p. 2408 - 2418
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Citation Number: 7
Abstract
We have previously identified phenylguanidine and phenyl-2-aminoimidazoline compounds as high affinity ligands with conflicting functional activity at the α2-adrenoceptor, a G-protein- coupled receptor with relevance in several neuropsychiatric conditions. In this paper we
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