Comparisons of phosphorothioate with phosphate transfer reactions for a monoester, diester, and triester: isotope effect studies

IE Catrina, AC Hengge

Index: Catrina, Irina E.; Hengge, Alvan C. Journal of the American Chemical Society, 2003 , vol. 125, # 25 p. 7546 - 7552

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Citation Number: 42

Abstract

Phosphorothioate esters are sometimes used as surrogates for phosphate ester substrates in studies of enzymatic phosphoryl transfer reactions. To gain better understanding of the comparative inherent chemistry of the two types of esters, we have measured equilibrium and kinetic isotope effects for several phosphorothioate esters of p-nitrophenol (p NPPT) and compared the results with data from phosphate esters. The primary 18O isotope effect ...