Azines and Azoles: CXX. Synthesis of Acyclic Analogs of N1-Ribosides of Barbituric Acid and Its 5-ylidene Derivatives

EP Studentsov, AN Kokhanovskii, MB Ganina…

Index: Studentsov; Kokhanovskii; Ganina; Nikolaeva; Fedorova; Moskvin; Ivin Russian Journal of General Chemistry, 2004 , vol. 74, # 2 p. 261 - 265

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Citation Number: 3

Abstract

Abstract The reaction of 2, 4, 6-tris (trimethylsiloxy) pyrimidine with 2-oxabutane-1, 4-diyl diacetate in methylene chloride in methylene chloride in the presence of SnCl 4 proceeds regioselectively to form 1-[(2-acetoxyethoxy) methyl] barbituric acid. The latter is readily deacetylated to a free acyclic analog of N-ribosides of barbituric acid. 1-[(2-Acetoxy-and 2- hydroxyethoxy) methyl] barbituric acids easily react with aromatic and heterocyclic ...