Degradation and disposal of some antineoplastic drugs

G Lunn, EB Sansone, AW Andrews…

Index: Lunn; Sansone; Andrews; Hellwig Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 8 p. 652 - 659

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Citation Number: 20

Abstract

Abstract Bulk quantities and pharmaceutical preparations of the antineoplastic drugs carmustine (BCNU), lomustine (CCNU), chlorozotocin, N-[2-chloroethyl]-N′-[2, 6-dioxo-3- piperidinyl]-N-nitrosourea (PCNU), methyl CCNU, mechlorethamine, melphalan, chlorambucil, cyclophosphamide, ifosfamide, uracil mustard, and spiromustine may be degraded using nickel-aluminum alloy in KOH solution. The drugs are completely ...