The Journal of Organic Chemistry

Synthesis of the main metabolite (OL-17) of cyclosporin A

MK Eberle, F Nuninger

Index: Eberle, Marcel K.; Nuninger, Francois Journal of Organic Chemistry, 1992 , vol. <9> 57, p. 2689 - 2691

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Citation Number: 42

Abstract

Cyclosporin A'(l), the active ingredient of Sandimmune, is a powerful immunosuppressant2 preventing organ allograft rejections in animals3 and human^.^ It is available from natural sources6 or through total synthesis. 6 The mechanism of action'is based on the inhibition of the production of lymphokines such as interleukine-2 (IL-2). Mainly, these lymphokines are secreted by the activated T helper cells thus stimulating the clonal expansion of activated ...