Synthesis of benzamide-C-ribonucleosides by Pd-catalyzed aminocarbonylations
M Štefko, R Pohl, M Hocek
Index: Stefko, Martin; Pohl, Radek; Hocek, Michal Tetrahedron, 2009 , vol. 65, # 23 p. 4471 - 4483
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Citation Number: 22
Abstract
A novel modular, efficient and practical methodology for preparation of p-and m-substituted benzamide-C-ribonucleosides was developed. Reaction of TBS-protected 3-and 4- bromophenyl-C-ribonucleosides 1 and 4 with various primary and secondary amines or NH4Cl under atmospheric pressure of carbon monoxide and in the presence of Pd (OAc) 2 and Xantphos lead to the corresponding amides 2a–j and 5a–j in high yields. Subsequent ...
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