Organic Syntheses

Nickel??Catalyzed Cross??Coupling of Aryl Halides with Alkyl Halides: Ethyl 4??(4??(4??methylphenylsulfonamido)??phenyl) butanoate

DA Everson, DT George

Index: Everson, Daniel A.; George, David T.; Weix, Daniel J. Organic Syntheses, 2013 , vol. 90, p. 200 - 214

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Citation Number: 11

Abstract

With no precautions to exclude air or moisture, a 500-mL round-bottomed flask is equipped with a PTFE-coated egg-shaped magnetic stir bar (38× 16 mm). 4-Bromoaniline (Note 2)(15.1 g, 88.0 mmol, 1.00 equiv) and p-toluenesulfonyl chloride (Note 3)(17.1 g, 89.8 mmol, 1.02 equiv) are weighed into plastic weigh boats and added to the vessel through a powder funnel. Dichloromethane (Note 4)(230 mL) is then poured into the vessel from a graduated ...