Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors

…, KE Rodriques, JB Summers, JF Dellaria…

Index: Kolasa; Brooks; Rodriques; Summers; Dellaria; Hulkower; Bouska; Bell; Carter Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 819 - 824

Full Text: HTML

Citation Number: 23

Abstract

Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such as ibuprofen, naproxen, and indomethacin were used as orally bioavailable scaffolds to design selective 5-lipoxygenase (5-LO) inhibitors. Replacement of the NSAID carboxylic acid group with a N-hydroxyurea group provided congeners with selective 5-LO inhibitory activity.