N-Alkylated 2, 3, 3-trimethylindolenines and 2-methylbenzothiazoles. Potential lead compounds in the fight against Saccharomyces cerevisiae infections

…, CL Lawrence, VC Jones, C Moffatt, RB Smith

Index: Tyler, Andrew R.; Okoh, Adeyi Okoh; Lawrence, Clare L.; Jones, Vicky C.; Moffatt, Colin; Smith, Robert B. European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 222 - 227

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Citation Number: 4

Abstract

The synthesis of a variety of N-alkylated 2, 3, 3-trimethylindolenines and 2- methylbenzothiazoles is reported herein. Their potential as antifungal agents is evaluated by preliminary screening against Saccharomyces cerevisiae (S. cerevisiae), Schizosaccharomyces pombe (S. pombe), and Candida albicans (C. albicans). Statistical analyses illustrate a strong relationship between chain length and growth inhibition for S. ...