Reaction of 2-Methoxy-3 H-azepine with NBS: Efficient Synthesis of 2-Substituted 2 H-Azepines

CEJ Cordonier, K Satake, M Atarashi…

Index: Satake, Kyosuke; Okuda, Ryoichi; Hashimoto, Michiaki; Fujiwara, Yasushi; Watadani, Izumi; et al. Journal of the Chemical Society, Chemical Communications, 1991 , # 17 p. 1154 - 1156

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Citation Number: 14

Abstract

The reaction of 2-methoxy-3 H-azepines, in the presence or absence of a nucleophile, with N-bromosuccinimide (NBS) gave a regioselective 1, 4-adduct from which the corresponding 2 H-azepine derivatives were formed via base-promoted hydrogen bromide elimination,

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