The structure of pradimicins A, B and C: A novel family of antifungal antibiotics

…, M Nishio, H Ohkuma, T Tsuno, M Konishi…

Index: Tsunakawa; Nishio; Ohkuma; Tsuno; Konishi; Naito; Oki; Kawaguchi Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2532 - 2536

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Citation Number: 59

Abstract

Although enormous screening efforts have been made in the past 30 years, there are relatively few antifungal antibiotics with clinical efficacy, particularly against systemic fungal infections. In our efforts to discover microbial metabolites active against fungal infections, we have found that cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557), isolated from a soil sample from Fiji Island, contained red pigments that strongly protected mice from