Evaluation of nitroalkenes as nitric oxide donors

MJ Gorczynski, J Huang, H Lee, SB King

Index: Gorczynski, Michael J.; Huang, Jinming; Lee, Heather; King, S. Bruce Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 2013 - 2017

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Citation Number: 26

Abstract

Chemiluminescence experiments demonstrate that simple nitroalkenes release low levels of nitric oxide. UV and EPR measurements suggest but cannot confirm direct NO release from nitroalkenes. Given the biological activity of nitrated unsaturated fatty acids, these results suggest the possible metabolic conversion of nitroalkenes to NO.