PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation

S Zhu, M Hong, L Zhang, G Tang, Y Jiang…

Index: Zhu, Saijie; Hong, Minghuang; Zhang, Lihong; Tang, Guotao; Jiang, Yanyan; Pei, Yuanying Pharmaceutical Research, 2010 , vol. 27, # 1 p. 161 - 174

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Citation Number: 136

Abstract

Abstract Purpose To investigate the effects of PEGylation degree and drug conjugation style on the in vitro and in vivo behavior of PEGylated polyamidoamine (PAMAM) dendrimers- based drug delivery system. Methods Doxorubicin (DOX) was conjugated to differently PEGylated PAMAM dendrimers by acid-sensitive cis-aconityl linkage and acid-insensitive succinic linkage to produce the products of PPCD and PPSD conjugates, respectively. In ...