Metabolic fate of fraxin administered orally to rats

…, T Nakazawa, A Hoshikawa, K Ohsawa

Index: Yasuda, Takaaki; Fukui, Mai; Nakazawa, Takahiro; Hoshikawa, Ayumi; Ohsawa, Keisuke Journal of Natural Products, 2006 , vol. 69, # 5 p. 755 - 757

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Citation Number: 21

Abstract

Naturally occurring fraxin (1) was administered orally to rats to investigate its metabolism. Urinary metabolites were analyzed by three-dimensional HPLC, and fraxetin-7-O-sulfate (2), fraxetin-7-O-β-glucuronide (3), fraxetin (4), 6, 7, 8-trihydroxycoumarin (5), and fraxidin (6) were isolated. Fraxin (1) was extensively metabolized to 4, which was partly metabolized to 5 in a rat fecal suspension after incubation for 24 h. Urinary excretion of 4 and 5 in rats ...