Tetrahedron

Synthesis and biological activity of C-4 and C-15 aryl azide derivatives of anguidine

SK Richardson, A Jeganathan, RS Mani, BE Haley…

Index: Richardson, Stewart K.; Jeganathan, Alwarsamy; Mani, Rajarathnam S.; Haley, Boyd E.; Watt, David S.; Trusal, Lynn R. Tetrahedron, 1987 , vol. 43, # 13 p. 2925 - 2934

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Citation Number: 7

Abstract

Potential trichothecene photoaffinity reagents were prepared by coupling either the C-4 or C- 15 alcohols derived from anguidine with (3-azido-5-methoxyphenoxy) acetic acid, 4-(3-azido- 5-methoxyphenoxy) butyric acid, or N-(3-azido-5-methoxyphenyl) N'-(carboxymethyl) urea. The C-15 anguidine deriviatives of (3-azido-5-methoxyphenoxy) acetic acid and (3-azido-4- iodo-5-methoxyphenoxy) acetic acid possessed protein synthesis inhibition activity ...