Discovery of 4-amino-2-(thio) phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. …

F Xu, L Zhang, Y Jia, X Wang, X Li, Q Wen…

Index: European Journal of Medicinal Chemistry, , vol. 69, p. 191 - 200

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Citation Number: 5

Abstract

... European Journal of Medicinal Chemistry. ... Replacing amide structure with sulfonamide structure fragment on considering its broadly biological activity in medicinal chemistry [13], [14 ... compounds 4a–j took Michael addition reaction [19] to gain the target compounds 5a–j and 5i1 ...