Tetrahedron: Asymmetry

An optically pure 1, 4-dihydropyridine from a resolution catalysed by rabbit liver esterase

CD Reeve, DHG Crout, K Cooper, MJ Fray

Index: Reeve; Crout; Cooper; Fray Tetrahedron Asymmetry, 1992 , vol. 3, # 6 p. 785 - 794

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Citation Number: 13

Abstract

Abstract The kinetic resolution of a precursor of the dihydropyridine UK-74,505, 1, an antagonist of platelet activating factor, is described, in which rabbit liver esterase was used to catalyse the hydrolysis of an ester function linked to the chiral centre via a spacer arm of appropriate length.