Journal of the American Chemical Society

A convergent strategy for synthesis of Erythrina alkaloids

CT Chou, JS Swenton

Index: Chou, Chun-Tzer; Swenton, John S. Journal of the American Chemical Society, 1987 , vol. 109, # 22 p. 6898 - 6899

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Citation Number: 20

Abstract

6 7 (67%) and heated to reflux for 1 h to effect the intramolecular cyclization. The resulting ketals were purified by chromatography on activity I11 neutral alumina and hydrolyzed with 5% aqueous acetic acid to give 5 (65% overall) and 7 (67% overall) after recrystallization. This chemistry demonstrated that both the B and C rings of the Erythrina skeleton could be formed via intramolecular cyclization. However, all attempts to hydrolyze the amide ...