Tetrahedron letters

Total synthesis of prodigiosin

DL Boger, M Patel

Index: Boger, Dale L.; Patel, Mona Tetrahedron Letters, 1987 , vol. 28, # 22 p. 2499 - 2502

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Citation Number: 52

Abstract

Abstract The total synthesis of prodigiosin (1), possessing the characteristic pyrrolylpyrromethene skeleton of a class of naturally-occurring polypyrroles, is detailed, The approach is based on the application of an inverse electron demand Diels-Alder reaction of dimethyl 1, 2, 4, 5-tetrazine-3, 6-dicarboxylate in a 1, 2, 4, 5-teirazine→ 1, 2-diazine→ pyrrole strategy for preparation of prodigiosin pyrrole ring B and the subsequent ...