Preparation of imidazo [2, 1??b] quinazolin??5 (3H)??ones and related tricyclic systems using a novel, double displacement reaction
NP Peet, J Malecha, ME Letourneau…
Index: Peet, Norton P.; Malecha, James; LeTourneau, Michael E.; Sunder, Shyam Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 257 - 264
Full Text: HTML
Citation Number: 9
Abstract
Abstract New methodology is described for the construction of tricyclic heterocycles. Thus, a double displacement reaction of l-(2-fluorobenzoyl)-2-methylthio-2-imidazoline (8a) with 1, 1- dialkylhydrazines gave 10-substituted 2, 10-dihydroimidazo [2, 1-b] quinazolin-5 (3H)-ones in good yield. The corresponding 1-(2-nitrobenzoyl)-2-meth-ylthio-2-imidazolines also underwent double displacement reactions with hydrazines. Other tricyclics made using ...
Related Articles:
Radical Synthesis of Guanidines from N??Acyl Cyanamides
[Larraufie, Marie-Helene; Ollivier, Cyril; Fensterbank, Louis; Malacria, Max; Lacote, Emmanuel Angewandte Chemie - International Edition, 2010 , vol. 49, # 12 p. 2178 - 2181]
[Yin, Ping; Liu, Nan; Deng, Yu-Xing; Chen, Yue; Deng, Yong; He, Ling Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2649 - 2658]
Synthesis of 4 (3H)??quinazolinones from derivatives of methyl 2??isothiocyanatobenzoate
[Dean, William D.; Papadopoulos, Eleftherios P. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1117 - 1124]
[Yin, Ping; Liu, Nan; Deng, Yu-Xing; Chen, Yue; Deng, Yong; He, Ling Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2649 - 2658]
[Pereira, Maria De Fatima; Alexandre, Francois Rene; Thiery, Valerie; Besson, Thierry Tetrahedron Letters, 2004 , vol. 45, # 15 p. 3097 - 3099]