Dependence of the reactivity of acridine on its substituents: a computational and kinetic study

Z Zawada, J Šebestík, M Šafařík…

Index: Zawada, Zbigniew; Sebestik, Jaroslav; Safarik, Martin; Bour, Petr European Journal of Organic Chemistry, 2011 , # 34 p. 6989 - 6997

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Citation Number: 4

Abstract

Abstract Aromatic nucleophilic substitution on the C9 carbon of acridine plays an important role in multiple biological and medicinal applications. The rate of the key reaction is strongly dependent on the environment and acridine substituents. In this study, the factors influencing the reaction mechanism were studied theoretically and verified experimentally for simplified systems. Density functional theory was used for the computations. The ...