A Practical and Efficient Vilsmeier Synthesis of 3-Chloroindole-2-carboxaldehydes

ZH Li, ZR Hu, RE Chen, WK Su

Index: Li; Hu; Chen; Su Organic Preparations and Procedures International, 2010 , vol. 42, # 5 p. 479 - 484

Full Text: HTML

Citation Number: 1

Abstract

The indole ring is regarded as a priviledged structural moiety in many naturally occurring alkaloids1 or synthetic drugs. 2 In particular, 3-chloroindole-2-carboxaldehyde derivatives display important pharmacological properties such as anti-HIV3, antitumor4 and anticancer activities. 5 Recently, some important papers have been published on the synthesis and functionalization of indoles. 6–8 Although the Vilsmeier cyclization of 2-[(carboxymethyl) ...