Synthesis of Functionalized Glutamine??and Asparagine??Type Peptoids–Scope and Limitations

C Cardenal, SBL Vollrath, U Schepers…

Index: Cardenal, Carmen; Vollrath, Sidonie B. L.; Schepers, Ute; Braese, Stefan Helvetica Chimica Acta, 2012 , vol. 95, # 11 p. 2237 - 2248

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Citation Number: 4

Abstract

Abstract N-Alkylated glycine oligomers ('peptoids') can serve as potent peptidomimetic systems. Installing different functional groups can often be a challenge, and minimizes yields and purities. Here, we describe the synthesis of different amide-containing submonomers which were obtained as free bases, as well as their incorporation into peptoids. By using the free amines, the coupling results on solid support could be improved, and various ...