Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl (phenyl) methyl]-1, 5-diphenyl-1H-pyrazoles

G Menozzi, L Merello, P Fossa, S Schenone…

Index: Menozzi, Giulia; Merello, Luisa; Fossa, Paola; Schenone, Silvia; Ranise, Angelo; Mosti, Luisa; Bondavalli, Francesco; Loddo, Roberta; Murgioni, Chiara; Mascia, Valeria; La Colla, Paolo; Tamburini, Elena Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 20 p. 5465 - 5483

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Citation Number: 73

Abstract

During the course of our studies in the azole antifungals area, we synthesized a number of 1, 5-disubstituted 4-[1H-imidazol-1-yl (phenyl) methyl]-1H-pyrazoles, analogues of bifonazole. 1, 5-Diphenyl-1H-pyrazole 3 showed weak antimycotic and antibacterial activities in vitro against Candida albicans, Cryptococcus neoformans and Staphylococcus aureus. In order to increase these properties, given that the halo substitution was found to ...