The urea-dipeptides show stronger H-bonding propensity to nucleate β-sheetlike assembly than natural sequence
D Ke, C Zhan, X Li, ADQ Li, J Yao
Index: Ke, Damei; Zhan, Chuanlang; Li, Xiao; Li, Alexander D.Q.; Yao, Jiannian Tetrahedron, 2009 , vol. 65, # 39 p. 8269 - 8276
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Citation Number: 8
Abstract
In this article, we report the distinct solution behavior of a set of urea-dipeptides to that of natural sequence. The urea-dipeptides adopt β-folding conformations and form into β- sheetlike assembly in chloroform. Most surprisedly, the urea-dipeptides tend to form interpeptide H-bonding interactions even at a concentration of as low as 0.1 mM, while the natural sequence shows H-bonding propensity at a concentration of about 7mM, ...
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