Synthetic Communications

Concise synthesis of photocleavable molecular tag for laser desorption ionization mass spectrometry via Fries reaction

JW Gathirwa, T Maki

Index: Gathirwa, Jeremiah W.; Maki, Toshihide Synthetic Communications, 2013 , vol. 43, # 7 p. 1016 - 1022

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Abstract

A new synthetic route for the photocleavable molecular tag for laser desorption ionization mass spectrometry (LDI-MS) was achieved using the Fries reaction of 2,6-dimethylphenyl ester as its key reaction. Zirconium chloride was used as uniquely efficient adjuvant to promote the reaction. The molecular tag was obtained in five steps without chromatographic purification. ... Supplemental materials are available for this article. Go to the publisher's online edition of ...