Il Farmaco

Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti-inflammatory and analgesic activities

…, R Cerri, F Palagiano, W Filippelli, G Falcone, E Lampa

Index: Pau, Amedeo; Boatto, Gianpiero; Cerri, Riccardo; Palagiano, Francesco; Filippelli, Walter; Falcone, Giuseppe; Lampa, Enrico Farmaco, 1998 , vol. 53, # 3 p. 233 - 240

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Citation Number: 4

Abstract

Two series of 1-methyl-4-(N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-(N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated in order to obtain a more exhaustive knowledge of the structure- activity relationship.